NIH Athymic Nude Mice

 

1 - 49 MICE

50+ MICE

AGE IN WEEKS
MALE
FEMALE
MALE
FEMALE
 4 $37.50 $42.00 $33.50 $37.00
5 or 6 $39.50 $45.00 $36.50 $41.00
7 to 9 $42.00 $49.00 $38.50 $43.00
 

Female with Litter-6 pups 
 $245.00
NIH Swiss Athymic Nude mice are bred and maintained under strict environmental conditions. The nu mutation was first reported in 1966 in a lab in Glasgow, Scotland. But it was two years later that it was discovered that a homozygous nude mouse also lacked a functional thymus. The mutation produces a hairless state and an ideal model for studying allografts, xenografts, tumorigenicity and cancer metastasis.

Although the nude mouse lacks T cells, it has a normal complement of bone marrow-dependent B cells. Nude mice also have elevated levels of both macrophages and NK cells; their macrophages are also more potent than those from mice with a normal functioning thymus.

Some other characteristics include:

  • A high incidence of glomerulonephritis by three months of age. This includes higher than normal deposits of IgG, IgM, and IgA.
  • Have normal hair growth cycles despite a hairless state
  • Have a low incidence of nonsuppurative dermatitis
  • Low incidence of keratoacanthoma and squamous carcinoma
  • Very high incidence of corneal vascularization

Athymic nude mice are produced by breeding heterozygous females with homozygous males. While homozygous females will carry litters to term, most pups will not survive due to poor lactation.

*Origin: To Ace from Taconic Farms, Germantown, NY, June 2002