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1
- 49 MICE |
50+ MICE |
AGE
IN WEEKS |
MALE |
FEMALE |
MALE |
FEMALE |
| 4 |
$37.50 |
$42.00 |
$33.50 |
$37.00 |
| 5
or 6 |
$39.50 |
$45.00 |
$36.50 |
$41.00 |
| 7
to 9 |
$42.00 |
$49.00 |
$38.50 |
$43.00 |
| |
Female
with Litter-6 pups |
$245.00 |
|
NIH Swiss Athymic Nude mice are bred and maintained
under strict environmental conditions. The nu mutation
was first reported in 1966 in a lab in Glasgow,
Scotland. But it was two years later that it was
discovered that a homozygous nude mouse also lacked
a functional thymus. The mutation produces a hairless
state and an ideal model for studying allografts,
xenografts, tumorigenicity and cancer metastasis.
Although the nude mouse lacks T cells, it has
a normal complement of bone marrow-dependent B
cells. Nude mice also have elevated levels of both
macrophages and NK cells; their macrophages are
also more potent than those from mice with a normal
functioning thymus.
Some other characteristics include:
- A high incidence of glomerulonephritis by three
months of age. This includes higher than normal
deposits of IgG, IgM, and IgA.
- Have normal hair growth cycles despite a hairless
state
- Have a low incidence of nonsuppurative dermatitis
- Low incidence of keratoacanthoma and squamous
carcinoma
- Very high incidence of corneal vascularization
Athymic nude mice are produced by breeding heterozygous
females with homozygous males. While homozygous
females will carry litters to term, most pups will
not survive due to poor lactation.
*Origin: To
Ace from Taconic Farms, Germantown, NY, June
2002
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